New publications from the HookerLab network. 

Check out publications including the first description of our F-18 labeled version of Martinostat in ACS Chemical Neuroscience. 


Jacob Hooker: Weaver of Brain Science (Feature in The Scientist)


Instructor, Dr. Changning Wang, funded to study HDAC expression in human HD patients

The Huntington's Disease Society of America recently selected Dr. Changning Wang, an Instructor in the Hooker lab at MGH, as a recipient of this year's HDSA HD Human Biology Fellowship. The Scientific Advisory Board of the Foundation stated that Dr. Wang's plan to explore the expression of Histone Deacetylases in the brains of Huntington's Disease patients was "exactly what we had in mind when the Human Biology Project was launched in 2013." This patient-centric research strategy will employ Dr. Wang's recently approved HDAC-targeted PET imaging agent, [11C]Martinostat, and help us to understand the role these epigenetic enzymes might play in disease. Congratulations Dr. Wang! We can't wait to see your results!


Jacob as "The Mind Mapper" in C&E News Talented 12

Jacob Hooker 


From C&E News:  

We like to pretend that the extraordinary young scientists profiled below gather regularly in a secret lair to plot how they'll fight global scourges such as climate change and human disease.

Editors can dream, right? Although the CO2 Wrangler and the Mind Mapper, as we've dubbed them, don't actually belong to a circle of superheroes (at least that we know of), they nevertheless strive each day to make the planet a better place.

Welcome to C&EN's first annual Talented 12 feature, in which we highlight path-paving young researchers and entrepreneurs who are using chemistry to solve global problems. Among other things, this impressive group is seeking ways to synthesize molecules in a more environmentally friendly way, developing methods to curb global warming by removing carbon dioxide from the air, and investigating the biochemical underpinnings of diseases to help find a cure.

We selected 12 of them as a nod toward their chemical roots: The International Union of Pure & Applied Chemistry defines the mole—a fundamental unit of measure for chemists—with respect to the number of atoms in 12 g of carbon-12.

You might not recognize the names of the dozen chemists on our list. Their research might not yet be on your radar. But we're convinced that if we hadn't put the spotlight on them, their secret identities would have eventually been revealed through their undeniable scientific feats.


Mike's paper on Salvinorin A published in Neuropsychopharmacology

Salvinorin A occupancy at KORSalvinorin A (from salvia) is a uniqe hallucinogenic compound that acts as a kappa-opioid agonist.  We characterized its immediate and persistent effects at the kappa-receptor in vivo using PET imaging. Congratulations Mike (and team!).  You can find the manuscript here or request a copy from us using the contact link.