The enabling technology that underlies PET is radiotracer chemistry. Thus, the continued success and expanded capability of PET relies on the development of methods to incorporate positron-emitting isotopes into compounds. Arguably, one of the most important isotopes for PET research is carbon-11 (t1/2 = 20.4 min) due to its ubiquity in pharmacologically active compounds and its favorable physical properties. Equally, if not more important for PET, is fluorine-18. The longer half-life of fluorine-18 (t1/2 = 109.8 min) enables multi-step radiotracer synthesis and distribution of the formulated radiotracer to distant PET-facilities. However, only a limited number of reactions that meet the special demands and constraints of carbon-11 and fluorine-18 chemistry have been developed; even fewer are routinely employed due to process complexity and/or the requirement for special equipment. In the HookerLab, we are expanding the types of molecules that can be labeled with a PET isotope. This will enable new radiotracer design for use in medical imaging.