Entries in Steph Lie (2)


First Summer Subgroup Meeting

This week, we summer students had our first, full subgroup meeting with Jacob, and, while it was a little intimidating at first, it was such a great learning experience that I really enjoyed it. Since this was the first time we exposed to each other’s projects, we spent a good portion of our time explaining the background behind them. I volunteered to go first, and through Jacob’s questioning throughout the whole meeting, I learned three major things:

  1. I thought I knew the fundamentals of the technology with which I am working (fMRI, MR-PET, baseline and blocking scans, etc), but during my short presentation, I realized that there were certainly some holes in my understanding, and fortunately they were quickly filled in that time. Even after reading some papers and plenty of Wikipedia articles, at the beginning of the summer, my understanding of all of this was quite hazy, but as I keep gathering these points of understanding and insight, the picture is becoming clearer and clearer. That understanding is making me really appreciate the technology I’m working with, and as everything starts to clear, I feel like I’m developing a stronger sense of ownership over my projects, which is exciting.
  2. I’m beginning to work on my skills at explaining what I do in science in layman’s terms. Jacob urged us to start our talks with something wicked big picture—in his words: “one step below ‘the brain is important’”—and we all struggled with it. I think that is because most of the time when we talk about our work in science, we’re in the academic setting where everything is either currently studying something in the sciences or they’ve somewhat recently seen the basics in high school. Honestly, coming into the meeting, I thought my skills in this department were decent, as I’ve done a fair amount of tutoring both formally and just with my friends/classmates, and in those sessions I could break down concepts into simpler terms. However, once again, they had a general exposure to the material to begin with, so I really wasn’t testing my skills fully. As someone who hopes to be a physician, especially a pediatric physician, the ability to describe physiological concepts to patients who could have little to no science background knowledge is absolutely crucial. Patients will want to know what’s going on in their bodies (and/or their children’s bodies), so doctors need to be able to tell them in a way that they’ll understand.  By the end of the summer, I want to get better at this.
  3. Okay, confession—and this might be blasphemy considering I’m working in a heavily chemistry-focused research group: I did not like taking organic chemistry this past year. I struggled through that class. Hard. I was given several packages of notecards worth of reactions and mechanisms to memorize over the course of two semesters, and I had to somehow memorize them and translate them into use when given a synthesis or product prediction problem. My bridge between that input and output was shoddy at best because I was probably missing some fundamental bits of understanding. The result? A pretty miserable two semesters and some hard feelings between orgo and me. However, when we were going through some of the reactions that my fellow interns were running, I was able to both see a real application for those piles of notecards, and I think I started to learn organic chemistry—and really learn it this time. The result this time? It was actually pretty fun! Even though I am not doing a lot of chemistry (in terms of running reactions, NMRs, TLCs, etc) myself this summer, I am excited about keeping up with what my fellow interns are learning as they do their chemistry-focused projects.  

While subgroup meetings are typically an hour long, we occupied Jacob for about two hours this past week. To me at least, those two hours were the furthest thing from time wasted, and I’m looking forward to learning more at our next meeting next week.

-Steph Lie


Fishing for Targets

Following precedent, I will begin by introducing myself. My name is Stephanie Lie, and I am a rising junior at Boston University's Sargent College of Health and Rehabilitation Sciences currently pursuing a degree in Human Physiology. Upon graduating, I hope to attend medical school, and I am excited to use this summer with the Hooker Group as an opportunity to explore the development and basic science behind some of the technology that I will potentially be using, from a clinical standpoint, in my future career, while also supplementing some of the topics I’m learning in school with some real life experience. Unlike my fellow summer interns, I have not ventured very far from the nest, as I was born and raised in a suburb outside of Boston, and I now attend school and work in and around the city. Therefore, outside of work within the group, I will not have to face the intimidating challenge of navigating a new city; instead, my challenges will lie in transitioning to the life of a suburban commuter and tackling the monster that is Boston auto traffic and the MBTA.

However, I digress. This summer I will be working under the guidance of Ronald on peripheral MR-PET imaging. I am currently looking at data from full body, NHP scans utilizing some of Changning’s HDAC inhibitor tracers that he’s developing for the brain, and hopefully I will find that they specifically bind outside of the brain as well. From the literature, I’m learning that HDACs appear to play an interesting, epigenetic role in many different conditions, whether it be neurodegenerative diseases, psychological disorders, or, of particular interest to me while working in the periphery, cancer. Because these new compounds are focused on use in the brain, my exploration of their effects in the rest of the body are much like that of a fishing boat moving out into uncharted waters: I will make educated guesses as to where to drop lines (or in my case, Volumes of Interest in the images) based on literature and my mentors’ advice, but like with most research, I run the risk of pulling up empty. However, high risk yields high reward, right? The idea of finding an area where one of these compounds effectively binds means potentially finding a tracer for earlier cancer detection in places buried in the thoracic cavity and abdominal region; as someone who wants to go into the medical field, the idea of developing these types of diagnostic tools is pretty cool.

While the overall idea of what I will be doing this summer appears quite straightforward, in my first few weeks here, I have learned and experienced one of the hallmarks of research: translating those ideas into a reality can be far from straightforward. In order to reach the point of textbook perfection that I have seen in my undergraduate courses thus far, there are plenty of imperfections and challenges to overcome first. So far, I’ve had to tackle the learning curves of using various types of imaging software, finding alternatives when the preferred system broke down, and learning the new languages of radiology and computer science, all while facing the challenges of working around the imperfections that come with real-life data acquisition. While it’s certainly been challenging, by single-handedly keeping Google, PubMed, and Wikipedia in business and exploring different computer programs, I’m starting to get my sea legs underneath me, and I’m very excited to see what’s at the end of my lines.    

- Steph Lie