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Monday
Nov182013

Santacruzamate A

Here in the Hooker Lab we have developed an HDAC inhibitor we call Martinostat that we are using as an imaging probe for PET. We were excited to see a new HDAC inhibitor in the literature termed santacruzamate.

So what is santacruzamate A? 

 The Panama-based International Cooperative Biodiversity Group (ICBG) has focused on natural product drug discovery from Panamanian plants and microorganisms with a particular emphasis on the discovery of antiparasitic and anticancer lead molecules. Work with marine cyanobacteria has been especially productive and a number of anticancer and antiparasitic agents have been isolated from these organisms. In a recent paper, the authors report on the isolation of a selective HDAC inhibitor with extraordinary potency against HDAC2, a class I HDAC enzyme. Due to the collection of the source organism from near Santa Cruz Island in Panama’s Coiba National Park, a UNESCO World Heritage Site, this carbamate derivative has been named santacruzamate A.

For more information, please chect out the paper here:

http://pubs.acs.org/doi/abs/10.1021/np400198r

http://www.flickr.com//photos/uconntoday/sets/72157632246777616/show/

Changning

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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate A
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    Hooker Research Group at MGH Martinos Center - Blog - Santacruzamate
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January 10, 2014 | Unregistered Commenterpoovar hotels

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August 20, 2015 | Unregistered CommenterFauzi

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